Brain structure and function will be compared in middle to late-age adults with asthma compared to healthy adults. Participants will fill out asthma and psychological questionnaires non-diagnostic. Healthy volunteers will undergo behavioral testing and imaging at a single timepoint. Outcome Measures. The National Institute of Health Sorting Working Memory Test is a computerized test that requires the subject to sequence sets of visually and auditorily presented stimuli pictures of animals and food in size order from smallest to biggest.
The examiner reads a list of 15 nouns aloud at the rate of one per second.
ABC's of Asthma
The National Adult Reading Test is a commonly used test to measure intellectual ability in English-speaking patients. We will assess brain functioning by measuring default brain network connectivity using functional magnetic resonance imaging fMRI. We will assess brain structure, hippocampal gray matter volume, using structural magnetic resonance imaging sMRI.
We will assess brain chemistry, specifically differences in hippocampal metabolite levels, using proton magnetic resonance spectroscopy 1H-MRS. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Inclusion Criteria: For asthma patients: diagnosis of asthma verified by a medical documentation for at least 2 years; for healthy volunteers: no significant medical or psychiatric history. Ages 40 to 69 years old. Proficient in English.
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Education level of at least 10th grade level. Exclusion Criteria: Treatment with oral corticosteroids in the previous 6 weeks, because of the potent effects of this drug on airway reactivity. Diagnosis of vocal cord dysfunction identified by abnormalities in spirometric flow-volume curves , clinically significant chronic obstructive pulmonary disease, or emphysema.
ABC of Asthma
Presence or history of medical or neurological disorder that may affect brain function and the physiological systems of interest e. Presence or history of Schizophrenia, Psychosis, or Dementia. Current or recent history within 1 year of Substance Related Disorders, current recreational drug use or consuming more than 20 alcoholic drinks per week. Current treatment with anti-psychotics, sedatives, benzodiazepines with a half-life longer than 6 hours.
Previous electroconvulsive therapy.
Not proficient in English. In the opinion of the principal investigator, participant is otherwise unsuitable for this study. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. Layout table for location contacts Contact: Collette B.
Airing Asthma’s Story
Bice, M. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Study Type :. Sign in to Purchase Instantly. Product Details. Average Review. Write a Review.
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